Maria Teresa Iorio

Supervisor: Marko Mihovilovic, Technical University of Vienna

Co-Supervisor: Margot Ernst, Medical University of Vienna


Title of the project: New Modifications of an old Scaffold: Pyrazoloquinolinone Derivatives and Analogs as Active Compounds on GABAA Receptors

Finishing date: 17.02.2020

Research topic of the student: Pyrazoloquinolinone Derivatives and Analogues as Active Compounds on GABAAReceptors. The aim of my project is to modify the general PQ scaffold in order to accomplish compounds with better properties in terms of selectivity, potency and detectability. So far, a library of compounds differently substituted in position 7 of ring A of PQ was synthesized to study the impact of R7 on activity of PQ derivatives in α6β3γ2. Furthermore, in order to gain more insight on the effect of changes at rings A and B of the general scaffold, we designed a new scaffold, in which the reduction of the size of ring B and the opening of ring C, herein resulted in a library of indole-derivatives.  



Research stays abroad30.05.2018 – 31.08.2018, Host: Christopher Ahern, Department of Molecular Physiology and Biophysics, Univ. of Iowa, USA; Topic: „Identifying the receptor for an ion channel therapeutic”

Lab Rotation (3+ weeks): Host: Harald Sitte, Institute of Pharmacology, Medical University of Vienna. Subject: Acquisition of experience in cell culture and performing upake and superfusion assays using monamines transporters; 2015

Place after graduation: Research Scientist at Takeda Pharmaceutical Company, Research and Development; Vienna

 Abstract of the PhD thesis

 Alumni brochure contribution by Maria Teresa Iorio