Dominik Dreier

Supervisor: Marko Mihovilovic, Technical University of Vienna

Co-Supervisor: Harald Sitte, Medical University of Vienna


Title of the project: Synthesis and Evaluation of Photoswitchable Monoamine Transporter Inhibitors

Research topic of the student: We aimed at establishing a comprehensive picture of key parameters for photoswitches within the application of this approach towards a photopharmacological platform for monoamine transporter inhibitors. Based on the available information from structural biology of such transporters, a particular case-study was envisioned to establish the first photo-switchable tool compound for this biological target (in particular aiming at SERT). The project involved an elaborate screening of various photo-switch motifs and the subsequent application of lessons-learned in the modification of established transporter inhibitor compounds (such as escitalopram and paroxetine). 

Finishing date: 08/2018


Research stays abroad: 30.06.2017 - 30.11.2017Host: Dalibor Sames, Dept. of Chemistry, Columbia University New York, USA: Topic: “Design, synthesis, and characterization of fluorescent substrates for the serotonin, norepinephrine, and dopamine transporters” 

Lab Rotation (2 weeks): Host: Harald Sitte; Topic: Molecular Docking, 11/2015

Place after graduation: since 10/2018: Junior Consultant (since 02/2020: Consultant) in the Boston Consulting Group, Vienna, AUT

 Abstract of the PhD thesis

 Alumni brochure contribution by Dominik Dreier