Details

Title of the project: New Modifications of an old Scaffold: Pyrazoloquinolinone Derivatives and Analogs as Active Compounds on GABA_A Receptors

Finishing date: 17.02.2020

Research topic of the student: Pyrazoloquinolinone Derivatives and Analogues as Active Compounds on GABA_AReceptors. The aim of my project is to modify the general PQ scaffold in order to accomplish compounds with better properties in terms of selectivity, potency and detectability. So far, a library of compounds differently substituted in position 7 of ring A of PQ was synthesized to study the impact of R7 on activity of PQ derivatives in α6β3γ2. Furthermore, in order to gain more insight on the effect of changes at rings A and B of the general scaffold, we designed a new scaffold, in which the reduction of the size of ring B and the opening of ring C, herein resulted in a library of indole-derivatives.  

Publications: https://www.ncbi.nlm.nih.gov/pubmed/

Research stays abroad: 30.05.2018 – 31.08.2018, Host: Christopher Ahern, Department of Molecular Physiology and Biophysics, Univ. of Iowa, USA; Topic: „Identifying the receptor for an ion channel therapeutic”

Lab Rotation (3+ weeks): Host: Harald Sitte, Institute of Pharmacology, Medical University of Vienna. Subject: Acquisition of experience in cell culture and performing upake and superfusion assays using monamines transporters; 2015

Place after graduation: Research Scientist at Takeda Pharmaceutical Company, Research and Development; Vienna