Details

Start of project:  01.10.2021

Title of the project:  Structure landscape analysis and functional mapping of disease-relevant mutations on SLC transporters

Research topic:  Jiahui Huang is a PhD student involved in the REsolution project. Her doctoral work is mainly focusing on structure function relationship analysis of the Solute Carrier (SLC) group of human transmembrane transporters. Through mapping disease-related mutations on three-dimensional structures or structural models of human SLCs, testable hypothesis of the functional influence of those mutations will be constructed. Moreover, for those mutations which are located in the active site, their possible impact on ligand binding will be further investigated. Ultimately, the aim is towards contextualizing structure/mutation-function relationship and to leverage this knowledge for innovative concepts for drug design.

Lab rotation: planned to be pursued in Fall/Winter 2022

planned topic: Simulate functional influence of disease-relevant mutations with  (targeted) molecular dnamic;

intended host lab: Chris Oostenbrink, University of Natural Resources and Life Sciences, Vienna