The Doctoral Program ION CHANNELS AND TRANSPORTERS AS MOLECULAR DRUG TARGETS („MolTag“)
is pleased to invite you to the following ONLINE lecture
"Activity-Based Sensing Approaches to Decipher the Elements of Cell Signaling”
by Christopher J. CHANG
Professor of Chemistry
Professor of Molecular and Cell Biology
Member, Helen Wills Neuroscience Institute
Adjunct Professor, UCSF
University of California, Berkeley, USA; College of Chemistry. Email: chrischang@berkeley.edu
Twitter: @christhechang; Webpage: https://chemistry.berkeley.edu/faculty/chem/chris-chang
on: Wednesday, November 3rd, 2021, 16:00/4:00 PM (CEST)
Host: Univ.Prof.Dr. Nuno Maulide, Organic Chemistry, University of Vienna
Meeting link: Please join our meeting from your computer or tablet:
https://global.gotomeeting.com/join/806004093
New to GoToMeeting? Get the app now and be ready when your first meeting starts: https://global.gotomeeting.com/install/806004093
Abstract: Traditional strategies for developing selective imaging reagents typically rely on molecular recognition and static lock-and-key binding to achieve high specificity. We are advancing an alternative approach to chemical probe design, termed activity-based sensing, in which we exploit inherent differences in chemical reactivity as a foundation for distinguishing between chemical analytes that are similar in shape and size within complex biological systems. This presentation will focus on development of activity-based sensing probes to visualize dynamic fluxes of transition metal ions and reactive oxygen species and their signaling and stress contributions to living systems, along with activity-based proteomics to identify novel targets and pathways that these emerging classes of chemical signals regulate. These chemical tools enable the discovery of new biology from transition metal signaling and metalloallostery to redox signaling.
For research interest and biography see: https://chemistry.berkeley.edu/faculty/chem/chris-chang
Contact: Doctoral Program MolTag; http://moltag.univie.ac.at/, Office.moltag@univie.ac.at
