Congrats to Aleksandra's 1st 1st author paper!

18.08.2022

In this joint MolTag paper, the authors identified a so far undescribed function of β-subunit homomers as proton-gated anion channels.

 

Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue.

This paper is a joint collaboration of 3 MolTag groups!

We congratulate the authors!

 

Garifulina A, Friesacher T, Stadler M, Zangerl-Plessl EM, Ernst M, Stary-Weinzinger A, Willam A, Hering S. :

β subunits of GABA A receptors form proton-gated chloride channels: Insights into the molecular basis - PubMed (nih.gov). Commun Biol. 2022 Aug 3;5(1):784. doi: 10.1038/s42003-022-03720-2. PMID: 35922471; PMCID: PMC9349252.

 

See here the Press release by University of Vienna (german).

Location of H267 in the pore region of the crystal structure of β3 homomers (the position of H267 is indicated with violet spheres). (© Theres Friesacher and Aleksandra Garifulina based on Miller et.al, 2014 DOI: 10.1038/NATURE13293)

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