Konstantina Bampali

Supervisor: Margot Ernst
Project: Subtype selective targeting of GABAA receptors

Mandatory Courses Completed Successfully
SubjectECTS pointsDate
Propedeutics: Ethics in Medicine and Good Scientific Practice - WS 2015110/2015
Basics of Neuroscience310/2015
Propedeutics: Scientific Software and Databases - WS 2015211/2015
Journal Club: Work in Progress101/2016
Journal Club: Brain Inflammation and Disease104/2016
Propedeutics: Methods of Life Sciences - SS 2016205/2016
Propedeutics: Intellectual property rights and project management - SS 2016105/2016
Ion channels and transporters as drug targets (2016S), UniVie206/2016
Journal Club: Peroxisomes - a key organelle in the battle between body and infectious agents 111/2016
Journal Club: Work in Progress101/2017
MolTag Journal Club101/2017
Basic Seminar: Lecture accompanied to Methods and Techniques in Neuroscience104/2017
TS: Methods and Techniques in Neuroscience (UE)1204/2017
TS Visualization and use of PDB data , MUW104/2017
Technical and epistemological challenges in protein-ligand complex crystal structure models 110/2017
Journal Club - Recent Trends in (Bio)Organic Chemistry, TU Vienna301/2018

Conference Talks
High affinity ligands selective for beta1-containing GABAA receptorsChemietage Salzburg, Austria09/2017

Conference Poster Presentations
Subtype selective modulation of GABAA receptorsFENS Forum 2016 Copenhagen07/2016
Molecular insights into subtype selective Modulation of GABAARsMolTag Science Day, Vienna11/2016
Molecular insights into subtype selective modulation of GABAA receptorsYoung Scientists Symposium at Medical University of Vienna06/2017
Structural analysis of novel GABAA receptor binding sites for the characterization of subtype selective ligandsAustrian Neuroscience Association Meeting, Klosterneuburg09/2017
Structural and pharmacological analysis of GABAA receptorsIon Channels Gordon Research Conference, Mount Holyoke College, MA, USA07/2018

Lab Rotations Completed Successfully
HostHost institutionSubjectDate of completion
Harald JanovjakInstitute of Science and Technology AustriaGeneration of chimeric gamma2 subunits of the GABAA receptor using Golden Gate cloning strategy12/2016

Internships Completed Successfully
HostHost institutionSubjectDate of completion
Stuart A. FORMANDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Boston, MA, USAGABAA receptor09/2018

Courses and Enabling Skills Seminars
Young Investigator Training Programme, FENS 2016 Copenhagen06/2016
Advances in Drug Discovery, Prague Summer School09/2016
Joint Meeting in Medicinal Chemistry, Dubrovnik06/2017
Training in interpersonal communication skills & conflict management in the workplace09/2017
Workshop "Career Paths for Natural Scientists", Univ. of Vienna01/2018

Publications in Peer Reviewed Journals
Genetic Variant in the CYP19A1 Gene Associated with Coronary Artery Disease.Genet Res Int. 2015;2015:820323. doi: 10.1155/2015/820323. 03/2015
Effects of ranolazine on left ventricular diastolic and systolic function in patients with chronic coronary disease and stable angina.Hellenic J Cardiol. 2015 May-Jun;56(3):237-41.06/2015
Carvedilol inhibits cADPR- and IP3-induced Ca2+ release.Messenger (Los Angel). 2016 Jun 1;5(1-2):92-99. doi: 10.1166/msr.2016.1050.06/2016
Molecular tools for GABAA receptors: High affinity ligands for ??1-containing subtypesSci Rep. 2017 Jul 18;7(1):5674. doi: 10.1038/s41598-017-05757-4.07/2017
Expeditious synthesis of polyacetylenic water hemlock toxins and their effects on the major GABAA receptor isoform.Chemical Communications, doi: 10.1039/c7cc09801d02/2018
Towards functional selectivity for alpha6beta3gamma2 GABAA receptors: a series of novel pyrazoloquinolinones.Br J Pharmacol.;175(3):419-428. doi: 10.1111/bph.14087. 02/2018
Engineered Flumazenil Recognition Site Provides Mechanistic Insight Governing Benzodiazepine Modulation in GABAA Receptors.ACS Chem Biol. 2018 Jul 23. doi: 10.1021/acschembio.8b0014507/2018
Diversity matters: combinatorial information coding by GABAA receptor subunits during spatial learning and its allosteric modulation. (Review)Cell Signal. 2018 Oct;50:142-159. doi: 10.1016/j.cellsig.2018.07.003. Epub 2018 Jul 11. Review.10/2018

TitleFunding organisationDate
FENS 2016 Travel GrantAustrian Neuroscience Association06/2016