Prof. Nuno Maulide

Modification of natural product structures by catalytic C-H activation.
There are several natural product GABA receptor activators and modulators known. We will prepare derivatives of a readily available such natural product through metal-catalysed sp3 C-H activation of suitable derivatives. This will enable the preparation of hitherto inaccessible analogues that can be tested for their biological activity towards GABA-A receptors.