Stefanie Kickinger

Supervisor: Ecker Gerhard
Project: GABA transporter selectivity profiling


Mandatory Courses Completed Successfully
SubjectECTS pointsDate
SE Ion channels and transporters as drug targets206/2016
PR Pharmacoinformatics Practical Course106/2016
VO Pharmacoinformatics106/2016
PR Praktikum aus Computational Drug Design608/2016
MolTag Journal Club, Medical Unviersity of Vienna101/2017
TS Visualization and use of PDB data, MedUni Vienna104/2017
Journal Club - Recent Trends in (Bio)Organic Chemistry Part 2, TU Vienna301/2018


Conference Talks
Subject/TitleConference/PlaceDate
Exploring a new allosteric binding pocket in the GABA transporter hBGT111th European Workshop in Drug Design (EWDD), University of Siena05/2017
Elucidating the molecular determinants for the subtype-selectivity of betaine/GABA transporter 1 (BGT1) inhibitorsThird Annual Research Student Symposium, American Chemical Society (ACS) New Haven Local Section, Quinnipiace University, New Haven, USA04/2018


Conference Poster Presentations
Subject/TitleConference/PlaceDate
Exploring the structure activity-relationship of novel non-competitive hBGT1 inhibitorseCheminfo Workshop, Milano07/2016
Molecular docking of novel non-competitive hBGT1 inhibitors to explore their structure-activity relationshipEFMC-ISMC 2016, Manchester08/2016
Exploring a new allosteric binding pocket in the GABA Transporter hBGT1MolTag Science Day, Vienna, AT11/2016
Inhibition of GABA transporters as promising drug target for treating epilepsyAnnual Conference of the Austrian Pharmacy Chamber, Schladming03/2017
Identifying the molecular determinants of inhibitors for the subtype-selectivity of the GABA transporter hBGT1Biomedical Transporter Conference, Lausanne08/2017
Investigating the molecular determinants governing the subtype-selectivity of GABA transporter 1 (BGT1) inhibitorsGordon Research Conference on Transmembrane Transporters in Health and Disease, Newry, USA07/2018
Synthesis, pharmacological activity and molecular modeling studies of a series of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogues as betaine/GABA transporter 1 (BGT1) substrate-inhibitors256th ACS National Meeting & Exposition, Boston, USA08/2018


Lab Rotations Completed Successfully
HostHost institutionSubjectDate of completion
Ass. Prof. Priv.-Doz. Dr. Margot Ernst, Margot Ernst, PhDMedical University of Vienna, Center for Brain ResearchHomology Modeling06/2016


Internships Completed Successfully
HostHost institutionSubjectDate of completion
Prof.Dr. William L. JorgensenDepartment of Chemistry, Yale University, New Haven/CT, USAFree Energy Calculations of Janus Kinase 2 inhibitors08/2018


Internships Planned
HostHost institutionSubjectDate of start
William L. JorgensenDept. of Chemistry, University of Yale...04/2018


Courses and Enabling Skills Seminars
SubjectDate
Expose and Outline Writing09/2016
Introduction to R11/2016
BioSolveIT Workshop (Introduction to SeeSAR a software tool for structure-based design)05/2017
PRACE Spring School, KTH Royal Institute of Technology in Stockholm, PDC Center for High Performance Computering (Molecular Dynamics simulation training in VMD, GROMACs and CHARMM)05/2017
Introduction to Inkscape (hands-on training for a vector graphics program)05/2017
"Basisqualifizierung fuer Erstlehrende - MINT-Faecher" (Teaching training)06/2017
Training in interpersonal communication skills & conflict management in the workplace09/2017
Career Paths for Natural Scientists, Workshop, University of Vienna01/2018


Publications in Peer Reviewed Journals
TitleJournal/VolumeDate
Damgaard M., Haugaard A.S., Kickinger S., Al-Khawaja A., Lie M.E., Ecker G.F., Clausen R.C., Frolund B. Development of non-GAT1 selective inhibitors; challenges and achievements. Advances in Neurobiology, volume 16 08/2017
Jorgensen L., Anas Al-Khawaja, Kickinger S., Vogensen S.B., Skovgaard-Petersen J., Rosenthal E., Borkar N., Loeffler R., Madsen K.K., Braeuner-Osborne H., Schousboe A., Ecker G.F., Wellendorph P., and Clausen R.P. Structure-activity relationship, pharmacological characterization and molecular modeling of selective non-competitive inhibitors of the betaine/gamma-aminobutyric acid transporter 1(BGT1). J. Med. Chem. (2017)11/2017
Kickinger S., Al-Khawaja A., Haugaard A., Loeffler R., Damgaard M., Gerhard E.F., Frolund B., Wellendorph P. Elucidating the molecular determinants for the subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogues as a novel class of betaine/GABA transporter 1 (BGT1) substrate-inhibitors. submittedJ. Med. Chem (2018)01/2018


Awards/Scholarships
TitleFunding organisationDate
Poster award for "Inhibition of GABA transporters as promising drug target for treating epilepsy"Austrian Pharmacy Chamber03/2017
"Best Oral Communication Award" Among Young Researchers Session Drug Design Workshop EWWD, Siena05/2017
Best Oral Communication AwardThird Annual Research Student Symposium, American Chemical Society (ACS) New Haven Local Section, Quinnipiace University, USA04/2018