Marco Stadler

Supervisor: Steffen Hering
Project: Molecular mechanisms of GABAA receptor and GLIC channel modulation


Mandatory Courses Completed Successfully
SubjectECTS pointsDate
SafeSciMet - 3.5 Mutagenesis and Carcinogenesis310/2015
Ion channels and transporters as drug targets206/2016
SE Journal Club: Biochemistry0.507/2016
MolTag Journal Club - Medical University of Vienna101/2017
TS Visualization and use of PDB data, MedUni Vienna104/2017


Conference Poster Presentations
Subject/TitleConference/PlaceDate
Synthesis and in vitro characterization of novel valerenic acid analogues on GABAA receptors derived from a ligand-based pharmacophore modelConference of the Austrian Pharmaceutical Society, Center of Pharmaceutical Sciences, Vienna09/2015
Valerenic acid serves as scaffold for the development of novel, subunit selective GABAA receptor modulators derived from a ligand-based pharmacophore modelAPHAR 2016 - Conference of the Austrian Pharmacological Society, Vienna09/2016
Valerenic acid serves as scaffold for the development of novel subunit selective GABAA receptor modulating anticonvulsants derived from a ligand-based pharmacophore modelSFN 2016 - Society for Neuroscience, San Diego11/2016
Natural compounds as scaffolds for novel GABAA receptor modulating anticonvulsantsMolTag Science Day, Vienna, AT11/2016
Pharmacological characterization of the first GLIC-beta3GABAA chimera4th Summer School on Advanced Drug Discovery09/2017


Lab Rotations Completed Successfully
HostHost institutionSubjectDate of completion
Thierry LangerUniversity of Vienna Novel subunit-selective GABAA receptor modulators and their putative binding site09/2016
Margot ErnstMedical University of ViennaStructural analysis of GABAA receptor vs. GLIC channels05/2017


Internships Planned
HostHost institutionSubjectDate of start
PJ Corringer/ Marc DelarueInstitute Pasteur, ParisCo-crystallization of GLIC and Valerenic acid derivatives04/2017


Courses and Enabling Skills Seminars
SubjectDate
FELASA B certificate - Veterinary University of Vienna10/2015
Lab visit, in vivo experiments, Medical University Innsbruck, Christoph Schwarzer07/2016
Lab visit Institute Pasteur, Paris (Pierre-Jean Corringer)11/2016
Prague Summer School - Advances in Drug Discovery09/2017


Publications in Peer Reviewed Journals
TitleJournal/VolumeDate
Preparative isolation of oleocanthal, tyrosol, and hydroxytyrosol from olive oil by HPCCCFood Chemistry03/2015
Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.British Journal of Pharmacology11/2015
HPLC-Based Activity Profiling for GABAA Receptor Modulators in Searsia pyroides Using a Larval Zebrafish Locomotor AssayPlanta Med05/2017


Awards/Scholarships
TitleFunding organisationDate
Best Poster Award4th Prague Summer School on Advanced Drug Discovery09/2017