Vienna University of Technology
Institute of Applied Synthetic Chemistry
The primary competence of the research group headed by Prof. Marko D. Mihovilovic is (bio)organic synthesis and medicinal chemistry. This includes special expertise in the synthesis of heterocyclic compounds as bioactive products using modern synthetic strategies such as metal-assisted catalysis and biocatalysis (esp. redox biotransformations). Very recently, his interest has also shifted to instrument assisted transformations, in particular utilizing continuous flow-devices. Apart from these aspects in synthetic chemistry, his core competence also includes all aspects of molecular biology associated to the generation and modification of isolated enzyme or whole cell biocatalysts. Generally, research activities are co-supervized by Dr. Michael Schnürch (medicinal chemistry, organic synthesis) and Dr. Florian Rudroff (biocatalysis, renewables). Research in medicinal chemistry focuses on instrument assisted lead compound development employing modern and modular synthetic strategies. Current application targets are in the area of modifying cell differentiation aiming at highly novel treatment regimes in regenerative medicine and improving sub-type selectivity of natural compound and synthetic product derived GABA-ligands.
Feb 2014 Appointed Full Professor for Bioorganic Synthetic Chemistry
Coordinator of the TU PhD Graduate School "AB-Tec"
Translational Research Center "Wings4Innovation"
Maria Teresa IORIO: Synthesis of novel ring structure as GABAA receptor ligands with functional selectivity
Daniela CINTULOVA: Enantioselective Synthesis of Configurationally Stabilized Methcathinones for the Investigations of Monoamine Transporters
Dominik DREIER: Optically Switchable Serotonin Transporter Ligands
David SIEBERT: Synthesis of binding site selective GABA A receptor ligands
Blanca VEGA ALANIS: Synthesis of novel scaffolds as selective ligands for the alpha+/beta- interface of the GABAA receptor