Univ. Prof. Dr. Gerhard Ecker

E-mail: gerhard.f.ecker@univie.ac.at

Group page:

Address:
University of Vienna
Dept. of Medicinal Chemistry
Althanstrasse 14
1090 Vienna
Austria


Researcher's Profile
Research interests:

  • Pharmacoinformatics
  • Transmembrane Transport Proteins
  • Structure-kinetics relationships

Gerhard Ecker heads the Pharmacoinformatics Research Group at the Department of Medicinal Chemistry, University of Vienna. He also coordinates the research focus "Computational Life Sciences" of the Faculty of Life Sciences. He studied pharmacy and received his doctorate in natural sciences form the University of Vienna under the supervision of Wilhelm Fleischhacker and Christian Noe. After his post-doctoral training at the group of J. Seydel in Borstel (Germany) he was appointed associate professor for medicinal chemistry at the University of Vienna in 1998 and is full professor for pharmacoinformatics from October 2009. He has published more than 100 articles related to SAR and QSAR studies on P-glycoprotein and his main scientific interests include pharmacoinformatic approaches to target drug efflux pumps, in silico high throughput screening methods for promiscuous targets and antitargets, and non-linear methods in drug design. Gerhard Ecker was vice-chair of the Senate of the University of Vienna 2006 – 2009, he is currently vice dean at the Faculty for Life Sciences of the University of Vienna, Vice-President of the Austrian Pharmaceutical Society and President of the European Federation for Medicinal Chemistry. From Oct 2009 on he also coordinates the EUROPIN PhD Programme in Pharmacoinformatics and is member of the research cluster (SFB) Transmembrane Transporters in Health and Disease, funded by the Austrian Science Fund.

Career highlights:

  • Since 2009 Full Professor of Pharmacoinformatics, University of Vienna
  • 2003 – 2009 Member and 2006 – 2009 Vice Chair of the Senate of the University of Vienna;
  • Since 2014 Vice Dean of the Faculty of Life Sciences, University of Vienna

Selected Grants and Awards:

Coordinator of the EUROPIN PhD Program in Pharmacoinformatics
Coordinator of the IMI project Open PHACTS
Editor Molecular Informatics

Ongoing MolTag Research projects as Supervisor:

Stefanie KICKINGER: GABAA receptor and GABA transporter selectivity profiling
Eva HELLSBERG: Selectivity Profiling of the human Monoamine Transporters: Uptake Inhibitors vs. Substrate Releasers
Sankalp JAIN: Structure and Ligand based approaches to target the two ABC-transporter BSEP and MDR3

Ongoing projects as Co-Supervisor:

Harald BERNSTEINER: Investigating inherited mutations in KATP channels causing Cantu disease
Tina HOFMAIER: The Impact of Phosphatidylinositol-4,5-bisphosphate (PIP2) on Serotonin Transport Function

Completed MolTag Research projects as Supervisor:

Daria GOLDMANN: Selectivity Profiling of Ligands towards GABAA and TRPV1 Receptors, finished 09/2015
Andreas JURIK: Comparative Modeling Studies for Profiling of the GABA Transporter System, finished 05/2015
Amir SEDDIK: Substrate Selectivity Profiling of Monoamine transporters, finished 07/2015

Completed projects as Co-Supervisor:

Saha KUSUMIKA: LRET-based distance measurements in the mammalian glutamate transporter EAAC1; finished 02/2016
Tobias LINDER: Pore gating of potassium channels and dissociation of hERG channel inhibitors; finished 12/2014
Santosh K. VENKATESAN: LRET-based distance measurements in a bacterial homolog to mammalian glutamate transporter GltPh; finished 02/2016